Padgetts disease of vulva

It occurs predominantly in postmenopausal Caucasian women [ 6 ]. Her fields of special interest and research include vulvar pathology and hereditary cancer. EMP presents as a pruritic or burning, scaly, erythematous and sometimes ulcerated plaque. Posted by Healing Miss Lily. Recent studies show that imiquimod cream may be an effective and safe alternative.
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extramammary Paget's disease

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Concerning the pathogenesis, it is still the subject of great debate. This website is intended for pathologists and laboratory personnel, who understand that medical information is imperfect and must be interpreted using reasonable medical judgment. Paget's disease of the vulva is caused by an abnormal change in the cells which cover the skin of the vulva. Long-term monitoring of patients is recommended, and repeat surgical excision is often necessary [ 24 ]. Involvement may be extensive including the perianal region, genitocrural, and inguinal folds. However, 20 studies were included in a narrative discussion in Effects of interventions.
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Paget’s Disease of the Vulva in Premenopausal Woman Treated with Only Surgery: A Case Report

Practically, the way forwards would be to design a large international multicentre trial, as well as carefully planned prospective data collection with consideration to bias. We set a cut-off of series with at least 10 women, in order to try to include as much of the published data as possible, while excluding case reports and very small case series. She presented with a large hyper-pigmented to pink plaque extending through the pubic area and left great labia Figure 1A. Probably because of its multicentric nature, Paget's disease has a chronic and relapsing course. The diagnosis is made by examination and tissue sampling. There were women included with some data for analysis. At every visit a visual examination is necessary in order to determine disease free status.
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Other flaws in retrospective data collection include a lack of clarity in decision making regarding choices of surgery and whether any other treatment options had been offered or discussed. Paget's disease of the vulva. Extramammary Paget's disease of the vulva and anus: What causes Paget's disease of the vulva? For a long time, the standard treatment for vulvar Paget's disease has been surgery with intraoperative margin control, but results have been very disappointing. The chemotherapy used was cisplatin plus fluorouracil.
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